8 Best Anxiety Medication for Dogs (Along with Natural Options Too)!



Meg Marrs


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Some dogs seem to walk through life without ever worrying about a thing – they’re just on a tail-wagging, ground-sniffing, face-licking adventure.

Other dogs go through life seeing potential danger around every corner. And these anxious pups need a little more love and effort to enjoy a high quality of life.

Fortunately, there are a number of ways to help soothe your frazzled pooch. We’ll dive into some of the most popular dog meds for anxiety below, as well as other techniques for calming an anxious dog.

Most Common Prescription Dog Anxiety Medications


Veterinarians often prescribe the dog anxiety meds detailed below to help provide anxious dogs with a little relief. It is often necessary to experiment with different medications to achieve success, so you’ll need to work closely with your vet until you find the best dog meds for anxiety that work to soothe your pup’s nerves.

  • Alprazolam – A common medication prescribed for humans that suffer from anxiety, Alprazolam is typically prescribed for dogs suffering from relatively severe anxiety. Alprazolam is usually administered daily, but it may take several weeks or months before you’ll see an improvement in your dog’s symptoms.
  • Diazepam – Another common antianxiety medication for humans, diazepam is sometimes administered to dogs as a dog anxiety medication before they must undergo a stressful situation. Diazepam depresses the activity is some portions of the brain, which in turn reduces the amount of anxiety they feel.
  • Lorazepam – A member of the same drug class as alprazolam and diazepam, lorazepam also works by depressing some of the brain’s activity, which helps to reduce anxiety. Lorazepam is usually administered on an “as needed” basis, rather than as a daily medication.
  • Amitriptyline – Amitriptyline is a medication that works by increasing the levels of serotonin and norepinephrine in your dog’s brain. These neurotransmitters help to elevate mood and dampen anxiety, thereby eliminating the problem. It is important to make any increases or decreases in your dog’s dosage slowly to avoid causing imbalances in your pup’s brain.
  • Buspirone – Buspirone is a relatively mild anti-anxiety medication that helps to boost the serotonin levels in your dog’s brain. It is typically used for dogs who suffer from mild anxiety, rather than those suffering from particularly severe cases of the disorder.
  • Clomipramine – Sold under the brand name Clomicalm, clomipramine also works by encouraging your dog’s brain to produce more serotonin and norepinephrine, which usually helps alleviate some of his anxiety. The FDA has approved clomipramine for the treatment of canine separation anxiety, but some vets use it to treat more generalized anxiety disorders as well.
  • Dexmedetomidine – Primarily used to treat phobias and the anxiety caused by loud noises (thunder, fireworks, etc.), dexmedetomidine actually works by reducing the amount of activity in some portions of your dog’s brain. Unlike many other antianxiety medications for dogs, dexmedetomidine is usually administered when necessary, rather than on a daily basis.
  • Fluoxetine – Fluoxetine is a drug that is classified as a Selective Serotonin-Reuptake Inhibitor (SSRI), which works by increasing the amount of serotonin in your dog’s brain. FDA-approved for the treatment of separation anxiety, fluoxetine is typically given as a regular, daily medication.

Don’t have a prescription? There are some dog anxiety supplements that serve as over-the-counter anxiety meds for dogs, but they are rarely quite as powerful and effective as prescription canine anxiety meds. However, some online vet consultation services will write you a prescription, which you can then order through an online pet pharmacy.

Non-Medicinal Remedies To Cure Dog Anxiety

Because medicine to calm dogs can cause a variety of side effects, many owners and veterinarians like to experiment with non-medicinal solutions first.

Some of these types of solutions may provide relief for your pooch and help reduce or eliminate his stress, anxiety, and worry.


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Best vest for dogs


A snug-fitting garment that swaddles your pup and helps him to feel a little calmer.

Developed by behavioral scientists, the Thundershirt is a nice alternative to medicines for many dogs, and it has proven to be an effective treatment for many anxious dogs.

Because the Thundershirt won’t cause any side effects and is one of the safest possible treatments for anxiety, it is often an ideal place to start, when searching for a solution to your dog’s anxiety. Read our full hands-on Thundershirt review to better assess if this anxiety wrap could be a good solution for your pup.

We also have a guide on how to create your own DIY Thundershirt if you’re not crazy about putting up money for the official version.

Chillout Treats

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VetriScience Calming Treat for dogs

Chillout Treats

Over-the-counter dog treats that are designed to reduce your dog’s stress and help him feel more comfortable and secure.

Comprised of colostrum (the very first bit of milk produced by a dog who has just given birth), vitamin B1 (thiamine) and an amino acid called L-Theanine, which is thought to boost serotonin production, Chillout Treats are designed to be administered about 30 minutes prior to a stressful event.

Chillout Treats have a delicious chicken-liver flavor that dogs love, so administering them is usually pretty easy.


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Adaptil Calming Pheromones

Special chemicals that trigger responses from other members of a given species – may also be helpful for curing your dog’s anxiety.

Adaptil Calming Pheromone Spray is a spray designed to emit calming pheromones. Owners have mixed results with these types of Adaptil pheromone diffuser sprays, but they’re an easy non-prescription option to try for dogs with anxiety.

Adaptil comes in the form of a calming dog collar too!

Rescue Remedy

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Back Rescue Remedy stress relief for dogs

Rescue Remedy

A homeopathic product that reportedly helps reduce anxiety in dogs.

Formulated from a variety of plant and flower extracts, Rescue Remedy contains no real medications, and the method by which it is reported to work remains unclear, but some owners have found it helpful.

We’re skeptical of it, but there’s likely no harm in trying it (provided your vet gives you the green light).

A Secure Crate

Dogs often feel safe when allowed to hang out in confined, dark spaces, probably because it simulates a den. But most owners use crates that are relatively open, and provide sight lines in all directions. Fortunately, there are two solutions:

  • You can fit your dog’s existing crate with a cover, which will make the crate darker and provide a greater sense of safety. Crate covers are also nice because you can use them when leaving the house, while taking them off once you get home.
  • You can purchase a crate that provides a relatively dark and cozy space inside. By simply using a dark and secure crate, you alleviate the need to use a cover. Additionally, many good crates for dogs with separation anxiety, which are often reinforced to help keep panicky dogs safe and secure if they freak out when you leave.

Dog Toys

If you can keep your dog busy and give him something to occupy his mind, you may be able to alleviate some of his anxiety – particularly if the anxiety occurs when you leave him alone.

Just about any safe chew toy will work, but interactive, mentally stimulating puzzle toys are even better. Many owners swear by giving their dog a good frozen stuffed Kong – just stuff the Kong with wet food, freeze it, and your dog will be too occupied licking up the treat to worry about whatever is making him nervous.

Just keep in mind that goodies like these are really only helpful for dogs with mild anxiety. If a dog has extreme or severe anxiety, they likely won’t eat at all.

Interactive Communication Devices

Thanks to the magic of technology, dog owners now have a number of different ways they can communicate with their canine from afar. By communicating with your pooch a little during the middle of the day, you may be able to reduce his anxiety a bit.

The best way to do this is through the use of a dog camera, allowing you to see and hear your pooch when you log onto the camera’s companion app. We recommend opting for a camera that can dispense dog treats, as can allow you to regularly treat your dog during high-stress occasions even when you’re away from home, helping to keep them calm as a result.

Management and Behavioral Strategies for Reducing Anxiety

Products and tangible items are not the only way to help reduce your dog’s anxiety, and many owners have success by implementing various management strategies. Some of the strategies that typically produce the best results include:

 Increase the amount of exercise your dog receives. Exercise can help your dog burn through some of his excess energy, and it also releases endorphins in your dog’s brain, which will help elevate his mood. Don’t forget that mental exercise is important too, so provide your pup with plenty of enrichment activities too.

Leave the home quickly and quietly. If you make a big deal out of leaving the home, your dog will think it is a big deal too. So, instead of engaging in long goodbyes, just grab your stuff and walk out of the house confidently.

Make your dog’s crate as comfy as possible. The more positively your dog views his crate, the less likely he is to experience anxiety when you put him inside and leave the house. You can give your dog treats inside his crate from time to time to help promote a positive association with the crate, and be sure to provide a comfy blanket or crate-appropriate dog bed inside, so he remains comfortable while waiting for you to return.

Adjust your schedule. You may be able to reduce your dog’s anxiety by altering your schedule a bit. For example, you may want to try running errands during his typical mid-day naptime. Alternatively, you could try to take him out for some playtime and exercise immediately before leaving.

Add another pooch to your family. Some owners have conquered problems with dog anxiety – especially separation-induced anxiety – by adding another pet to the home. This isn’t always an effective strategy, and you should always think carefully before bringing home a 2nd dog, but a playmate might help keep your anxious dog company and prevent him from feeling lonely.

Take your dog with you when you need to leave. If nothing else works, you may find that the best solution is to simply take your dog with you whenever possible. You’ll need to ensure your dog is very well-behaved in public to do so, but this can all but eliminate the problem of separation anxiety for many dogs.

Symptoms of Anxiety in Dogs

anxiety medication for dogs

Your dog can’t tell you he is anxious, so you need to familiarize yourself with some of the most common signs and symptoms of canine anxiety.

No single symptom is definitive, and some dogs may exhibit one or more of these symptoms without necessarily being anxious. However, the following signs certainly warrant further investigation.

  • Inappropriate Elimination – Housebroken dogs who poop or pee in inappropriate places are often exhibiting the signs of anxiety. Note that this doesn’t mean your dog is anxious just because he has an accident, but if it occurs more than once or twice, you should probably investigate the possibility that he is more nervous than normal.
  • Clinginess – Dogs that hover around their owners obsessively are often consumed with worry. It can, however, be difficult to distinguish dogs who simply love being near their owners, with those who are doing so as a coping mechanism, but your vet or a behavioral therapist may help you figure out the cause.
  • Destructive Chewing – Dogs often try to alleviate their anxiety by chewing on various items, and many will select things that smell strongly of their owners. So, if your pooch decides to start chewing on your shoes or the remote control for your TV, he may be suffering from an unhealthy level of anxiety.
  • Trembling Shaking or trembling is a common sign of anxiety. It is probably most common among smaller dogs, but even the biggest pups may shake if they are sufficiently nervous.
  • Panting – Dogs pant for a variety of reasons, such as when they are hot, tired or excited. However, panting can also indicate anxiety, particularly if it occurs when your dog is neither hot nor tired.

If you suspect your dog is suffering from anxiety, it may be smart for you to read up on canine calming signals – these are small body language cues dogs use to illustrate discomfort or stress.

Being aware of these indicators can help give owners a richer understanding of what’s happening in that canine noggin’.

Why Do Dogs Suffer from Anxiety?


Canine anxiety can arise for a variety of reasons, and it is important to familiarize yourself with some of the most common ones, to have the best chance of helping your dog feel better.

Note that some poor pups become anxious for multiple reasons, rather than a single cause. However, some common causes include:

Past Trauma

It’s depressing to think about, but many dogs experience anxiety as a result of a past traumatic incident (or, in particularly heart-breaking cases, multiple traumatic incidents). Examples include conflicts with other dogs, serious injuries, or run-ins with despicable humans.

If you’ve raised a dog since puppyhood, you may have an idea of what potential past traumas may be haunting your pooch. However, if you’ve only had your dog as an adult or got them from a shelter, your dog’s past traumas may forever remain a mystery.

Even without knowing the specifics of your dog’s traumatic incidents, you and a canine behavioral therapist should be able to work together to work past your dog’s issues.

Poor Socialization

Dogs who don’t get to meet plenty of people and other dogs when they are young may experience anxiety during encounters later in life.

This is why it’s so important to socialize your puppy early on to all different ages, races, and types of people. Neglecting this puppy parental duty can cause big issues in the future.


Some illnesses and chemical imbalances can cause pups to suffer from anxiety. This includes things that fall into the mental illness category as well as more typical illnesses, including everything from viral or bacterial infections to cancer. This is one of the reasons it is so important to work with your vet while trying to cure your dog’s anxiety.

Frightening Stimuli

Some dogs experience anxiety in direct response to specific stimuli, such as fireworks, thunder, or unfamiliar smells. These types of things usually only cause temporary anxiety, which resolves shortly after things go back to normal.


Some dogs become extremely anxious when separated from their humans (some can also become anxious when separated from other dogs they’ve bonded with).

Owners may mistake separation anxiety for devotion, but make no mistake – separation anxiety is unhealthy and is the results of an unconfident, insecure dog. Owners should always do their best to alleviate dog separation anxiety – your dog will be happier and don’t worry, they won’t love you any less!

Social Strife

Sometimes, certain dogs cause other dogs to feel anxious. Sometimes dogs overtly bully other dogs, but in other cases, the intimidation inflicted is very subtle, and often goes unnoticed by owners. Again, this is when knowing your canine calming signals can really come in handy!

Do you have an anxious dog that needs help relaxing? What types of strategies and techniques have you implemented? Were they successful, or did you end up at the vet’s office seeking additional help? Are there specific things that cause your dog anxiety or does your dog remain nervous all the time?

Let us know all about your experiences in the comments below!

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Written by

Meg Marrs

Meg Marrs is the Founder and Director of Marketing at K9 of Mine. She is a lifelong canine enthusiast and adores dogs of all shapes and sizes! She loves iced coffee, hammocks, and puppy-cuddling!

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  1. Ken Avatar

    Great article! We have a one year old Golden Retriever, Lucy. She is the smartest dog we have ever seen. We have high hopes for her and she completed Adult 2 dog classes when she was 8 months old! However, she is ambidextrous and my understanding is dogs who are ambidextrous tend to have problems with anxiety. She live on a Green Way which is a great place to walk a dog. Lucy refuses to walk on it. She does not like to play much either. She will chase the ball once in a while. She refuses to walk, she will sit down or turn around wanting to turn back to her yard. She loves her house, yard, and car. That is it. She likes to be with me and my wife. Everything else causes her anxiety. I would love to walk her for miles and throw the ball day, yet that is not the way this is going. Any suggestions would be much appreciated. And yes we socialized her as a pup and she loves people, especially kids. She is also good with other dogs. It is basically any sudden noises and car backfires and so on. I do not like car backfires that I am right next to but for Lucy the back fire could be 20 miles away and she wants to go home. Any ideas would be accepted.

    1. Ben Team Avatar

      Hey there, Ken. Thanks for the kind words about the article.

      It definitely sounds like Lucy is dealing with some anxiety, so we’d encourage you to reach out to a veterinary behaviorist if at all possible. In the meantime, you may want to check out our article about helping fearful dogs gain confidence.

      Best of luck!

  2. Michele Avatar

    Such a helpful and informative article! With the push to “adopt not shop” people should realize that shelter and rescue pets can oftentimes come with excessive emotional baggage that is harmful for both the pet parents and the pets themselves. Our family has found thar calming aids like adaptil, CBD, and Zylkene (milk proteins) only work in the mildest cases. Sometimes RX medication (coupled with consistent positive method training) is the only thing keeping the pet from an untimely death. No one likes to resort to medication, but too many pets are placed in shelters or euthanized because pet parents and some vets see medication as a lazy or harmful solution. This is a fatal error. When the animal is stressed, they are suffering. They cannot be trained to learn new behaviors when their anxiety is off the charts.
    Our latest shelter dog has a dark triad of behavioral issues-extreme separation anxiety, leash reactivity, and resource guarding. He cannot have a soft bed or blanket in his crate because he eats anything soft. He also has started marking in the home even though he’s potty trained. Anxiety is stealing his quality of life. He receives a ton of love, attention, stimulation and positive reinforcement. But with all due respect to The Beatles, sometimes love is not all you need.
    Medication is not a magic wand, but it takes the edge off and allows us to work with him to slowly reveal the dog he potentially could be.
    Thank you again for this article. It’s important to know that using medication is a tool, like training, and not a crutch or weakness but a heroic gesture.

    1. Ben Team Avatar

      Thanks for the kind words, Michele! We’re glad you appreciated the article and wish you the best of luck with your little guy!

  3. Joey Avatar

    great info, thank you

  4. Maria Arrington Avatar

    Thanks a lot for suggesting this medication.

  5. Cynthia Estep Avatar
    Cynthia Estep

    My puppy is 9 months old she plays for about 5 minutes with her toys and only about 10 with me. When in my lap she occupies herself at the most
    15 to 20 seconds.. She is very hyper when out of her crate but stays almost 6 or 7 hours in her crate.. She chews her chew toys to pieces!!

  6. Nicki Avatar

    I just ordered a stormdefender jacket for my dog Mac. He is a pit mix. He gets extremely agitated during storm events, and we have come to the conclusion that it is not the noise, or flashes, or rain. It’s either the static electricity or the barometric changes. Maybe he gets a massive headache. But he does seek grounded areas, like the toilet. Yuck. So maybe it is the static electricity. I hope the storm defender jacket helps.

  7. imgrum Avatar

    Thank you for sharing the post! It’s very helpful for me.

  8. Jenny H Avatar
    Jenny H

    Extreme anxiety can also be (maybe usually is?) due to genetics. I have a very anxious dog at this moment. She was my own pup, and I had her mother, and both Grandparents. Ther seemed no reason at all for her extreme timidity — until I spoke to the Stud Dog’s Owner. She told me that he was also Clingy — she said “He’s my dog . He always wants to be with me, or near me.”
    Sallee needs constant socialisation or she reverts to her shivery mess. (But she is a lovely lovey dog for me.)

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