15 Great Dane Mixed Breeds – Gentle Giants In Great Variety!

Mixed Breeds By K9 of Mine Staff 3 min read May 25, 2022 9 Comments

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great dane mixes

When mentioning the name “Great Dane”, size is usually the first thing that comes to mind.

While this animal can reach a record height and weight, and definitely needs plenty of space to stretch those long legs, the Great Dane breed is an incredibly friendly and lovable companion and a great addition to any household!

Breeding the Great Dane with other dog species has resulted in some pretty awesome combinations. We’ve compiled a list of the top Great Dane mixes for you to pick your favorite.

1. American Bull Dane: American Bulldog x Great Dane

Combining bloodlines of the Great Dane with the American Bulldog can result in this adorably relaxed creature called the American Bull Dane.

2. American Foxy Dane: Great Dane x American Foxhound

Consider yourself lucky if you should become an owner of this beauty, the American Foxy Dane, a cross-breed between the Great Dane and American Foxhound.

3. Boxdane: Great Dane x Boxer

Or how about spending valuable hours chatting to this absolutely inquiring personality – a mix between the Great Dane and Boxer, giving you a Boxdane?

4. Daniff: Great Dane x Mastiff

The combo Great Dane and Mastiff will result in this hulk of a companion, named the Daniff.

5. Doberdane: Great Dane x Doberman

Mixing Doberman genes with the Great Dane produces the Doberdane. This is one striking animal!

6. Great Bernard: Great Dane x Saint Bernard

Is this a horse or is this a dog? This is the beautiful Saint Bernard crossbreed gives us the Great Bernard – a mixture of the Great Dane and Saint Bernard.

7. Weiler Dane: Great Dane x Rottweiler

This adorable frown belongs to the Weiler Dane, a stunning mix of the Great Dane and Rottweiler.

8. Great Danebull: Great Dane x Pit Bull

Muscle and brute strength are the attributes of our Great Danebull, a cross between the Great Dane and Pit Bull.

9. Great Dane x Basenji

“All the better to hear you with Ma!” This cutie is the result of mixing the DNA of the Great Dane with the Basenji.

10. Great Pyredane: Great Dane x Great Pyrenees

This innocent face belongs to the crossbreed, the Great Pyredane, a hybrid dog breed cross of the Great Dane and Great Pyrenees.

11. Great Rottsky: Great Dane x Siberian Husky

How about this beaut? This is the Great Rottsky, a combo Great Dane and Siberian Husky.

12. Great Shepherd: Great Dane x German Shepherd

What you mean you’re getting a cat? The Great Shepherd is half Great Dane and half German Shepherd. And no, he does not particularly like felines…

great dane german shepherd

13. Great Wolfhound: Great Dane x Irish Wolfhound

An incredible mix of the Great Dane and Irish Wolfhound, giving us the Great Wolfhound.

14. Great Retriever: Great Dane x Golden Retriever

Awwww… The cute-as-a-button Great Retriever got her looks from mom Great Dane and her brains from pop Golden Retriever.

15. Labradane: Great Dane x Labrador Retriever

What do you get when you mix the larger-than-life Great Dane with the fan-favorite Labrador Retriever? One adorable, sweet, and gigantic all-star! The Labradane mix of Great Dane and Lab is becoming increasingly popular. One look at this face, and it’s no surprise why!

Unfortunately, all good things must come to an end, and so too our list of amazing Great Dane mixes has reached its end.

Please drop us a comment on what you think of our combinations and remember to send us a photo of your pride and joy Great Dane cross-breed. Until next time…

If you love big boys, make sure to also check out our guides to:

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Carrel Hamilton

I have a great dane pitbull and Australian shepherd mix he is very protective and wide open I try to socialize him but he doesn’t like other dogs except my other dog which is a pure breed husky I use her as his emotional support dog she helps him calm down a little in public he tries to copy wut she does he is 8 months husky is 9 yrs old does anybody have any advice on training him he is smart he sits gives paw does high 5 lays down and speaks while in house but out side he wont listen he is always in attack mode and I cant break him even with fly swatter with in house he is scared of terrified of actually in house but dont care outside would like to take him hiking and swimming at a river or lake but cant he barks growls around people and other animals

Ben Team

Hey, Carrel.
Your use of the phrase “attack mode” is pretty concerning, especially given the size of your pooch.
Anytime you’re faced with aggression issues, you will really need to work with a canine behaviorist — and the sooner the better.

I’m not sure if I completely understand the “fly swatter” comments, but just to be clear: Don’t hit your dog with a fly swatter — that’ll only exacerbate any fear or frustration he’s feeling and damage the trust between the two of you.
Best of luck!

Grizz The Danesky

Actually, the great dane and husky mix is called a Danesky! You can check out what danesky’s look like by going to @daneskydrama and/or @grizzthedanesky on Instagram ♡

Shanna Meyer

Looking for a breeder that may have a daniff to French mastiff mix. Not just daniff
Specifically daniff to French mastiff. Any info would be so great!

Jeraldine Knittle

I just had to put my greatdane aredale mix to sleep she had cancer in her lyphnoids i would really like to find another one like her. Could anyone help me. Gypsy was also my service dog and best friend.


Good day. My son had a great dane but he died from blood cancer. His hart broken. Can jy tel me the prices of the dogs please

Meg Marrs

They aren’t for sale – this is just a collection showing some of the cute mixes that come from Great Dane crosses!


My son brought home a big dog,the people at the pound,told him the dog was four years old,this so-called dog,in my opinion is a puppy,my best friend had great Dane,when I was a kid and this guy looks just like my friend’s dog when it was a puppy,i feel we have a great Dane/pit bull cross breed.he is a great looking puppy and I fell in love with him the moment I saw him,his name is Tanner.

Meg Marrs

Aw, say “hi” to Tanner for us!


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