Can I Give My Dog Zyrtec?

Medications By Ben Team 6 min read May 24, 2021

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zyrtec for dogs

It’s no fun to watch your poor pup repeatedly lick at her sides, haunches, and tail in an effort to scratch her unrelenting itches.

Fortunately, dogs respond well to many of the same medications that alleviate itchiness in people, and with your veterinarian’s consent, you can give her cetirizine, better known by the brand name Zyrtec.

Key Takeaways: Can I Give My Dog Zyrtec?

  • Just like humans, dogs can suffer from allergies. These allergies often cause very itchy skin, which can end up making your dog miserable if not addressed.
  • While the best option is always to identify and avoid the substance that’s triggering her allergies, sometimes this is impossible, and it becomes necessary to simply treat her symptoms.
  • Antihistamines are often used to treat itchiness in dogs, and Zyrtec is one of the antihistamines vets often recommend. Zyrtec is largely considered safe for dogs, but you should always obtain the green light from your vet before administering it (or any medication) to your dog.

First Thing’s First: Talk to Your Veterinarian

The first thing you should always do when your dog suffers from an itchy skin condition is consult your veterinarian.

Dogs itch for a variety of reasons, so your vet will begin by trying to identify the cause of the problem. He or she will check your dog for fleas, mites, lice, and other parasites, and likely inquire about the timing of the itchiness (many environmental allergies vary over the course of the year).

Some veterinarians will also take blood samples for laboratory testing or perform intradermal testing, to help identify the culprit. But unfortunately, the identity of many allergens remain elusive. Blood samples often disagree with each other and with the results of a skin test, making it difficult to come to a clear conclusion.

can dogs have zyrtec

Since it’s difficult to avoid contact with an unidentified allergen, the only option available for many dogs and their owners is to accept living with the mystery allergen and instead focus on treating the symptoms.

Why Do Dogs Itch?

Backing up a bit, it is important to understand why dogs (and humans, for that matter) get itchy.

When your dog is exposed to an allergen, some of the cells in her body release chemicals called histamines. These little chemical messengers travel through the bloodstream, seeking out cells that have the receptor to which they connect. Once they attach to the proper receptor, itchiness and other allergy-related symptoms occur.

There are different types of histamine receptors, and each responds differently once activated. Some cause smooth muscle constriction and an increase in stomach acid production, but others essentially elicit an inflammatory response – these are the receptors that lead to itching. Scientists call these receptors the H1 receptors.

Once stimulated, these receptors signal the blood vessels near the skin to dilate, which leads to redness, swelling and itching.

Antihistamines for Dogs

Now that it is clear your dog’s itching is caused by chemicals called histamine, it’s time to talk about the medicines that may help eliminate (or at least reduce the severity of) the problem.

Because doctors and veterinarians are more interested in treating patients than devising clever names, they simply call these medicines antihistamines.

Antihistamines can work in several different ways, but many block one of the types of histamine receptors – particularly the H1 receptor (you can check out this link, if you’d like to read about the finer points of histamines and their receptors).

zyrtec for dogs

Benadryl: 1st Generation Antihistamines: Effective But Makes Dogs Drowsy

There are a few different types of antihistamines. One of the most common is diphenhydramine, which is sold under the brand name Benadryl.

Like several other related drugs (collectively called first generation antihistamines), Benadryl is often effective for reducing itching and other allergy symptoms.

The problem with Benadryl and other first generation antihistamines is they often cause extreme drowsiness. Benadryl is safe to administer to canines in reasonable doses (and with veterinary approval).

Giving these types of medicines to your dog can help them feel better, but it will also turn her into a sleeping, snoring lump of fur.

Zyrtec: 2nd Generation Antihistamines: Fewer Doses Needed & No Sleepiness

Fortunately, pharmacists have developed a second generation of antihistamines, that work through slightly different biochemical means. Second generation antihistamines require less frequent dosing, do not cause drowsiness, and can often be administered once per day.

As you may have already figured out, Zyrtec is a second-generation antihistamine, and it is a valuable tool in treating dogs who have not responded to first-generation drugs.

Avoid Combination Antihistamines

While Zyrtec is generally regarded as safe for dogs, it is not formulated specifically for them – it is designed to alleviate your allergy symptoms, not your pup’s.

Because they cater to humans, Zyrtec (and many other antihistamines) often contain additional medications to help make allergy-suffering people feel better.

For example, many formulations include anti-inflammatory medications or pain killers, like acetaminophen or ibuprofen. Others are made with decongestants, like pseudoephedrine.

These medications can be dangerous for dogs, so it is imperative that you avoid such combination products.

Zyrtec For Dogs: Efficacy and Side Effects

Although Zyrtec helps a lot of dogs feel better, it isn’t always effective. In fact, a 2004 study published in The Canadian Veterinary Journal, found that Zyrtec only relieved the symptoms of 18% of the dogs in the trial.

However, as explained by the study’s authors, this efficacy rate is better than any other histamine tested in a similar manner, with one exception: the drug clemastine. Sold under the brand name Tavist, clemastine was able to control itching in about 30% of the dogs that participated in a different trial.

In light of these results, some authorities consider antihistamines to be largely ineffective in treating itching. Instead, they advocate for the use of glucocorticoids (a type of steroid), and encourage the inclusion of fatty acids in the diet.

Still, for most owners Zyrtec is a relatively safe option for dogs. Even with questionable efficacy, it’s worth a shot for alleviating allergy symptoms (assuming your vet agrees).

Zyrtec doesn’t often cause side effects, and most dogs tolerate it well. When side effects do occur, they are relatively mild — vomiting is the most commonly seen side effect, although some dogs also began to salivate heavily after being administered the drug.

Recommended Zyrtec Dosages For Dogs

Always consult with your veterinarian before offering Zyrtec, or its generic version cetirizine, to your pup – particularly if she’s never taken the medication before. However, most published accounts recommend similar dosages.

American Animal Hospital provides the simplest dosing instructions: They advise owners to give dogs less than 10 lbs half of a 10-milligram tablet (or a full 5-milligram tablet) each day, but owners of larger dogs should give their pet one full 10-milligram tablet each day.

Cheyenne West Animal Hospital provides a slightly more complicated regimen, as they recommend giving dogs different dosages based on a variety of sizes.

  • Dogs weighing up to 15 pounds: One 5-milligram tablet a day
  • Dogs weighing between 15 and 40 pounds:  One 5-milligram tablet every 12 hours, or one 10-miligram tablet every 24 hours
  • Dogs who weigh more than 40 pounds: One 10-milligram tablet every 12 hours


Have you ever used Zyrtec (or a generic version of cetirizine) to treat your dog’s itching? We’d love to hear your experiences. Did it help stop the itching? Did your dog experience any unpleasant side effects? Let us know in the comment section below.

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Written by

Ben Team

Ben is the managing editor for K9 of Mine and has spent most of his adult life working as a wildlife educator and animal-care professional. Ben’s had the chance to work with hundreds of different species, but his favorite animals have always been dogs. He currently lives in Atlanta, GA with his spoiled-rotten Rottweiler named J.B. Chances are, she’s currently giving him the eyes and begging to go to the park.


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